MAPT and Alzheimer disease: Of note is that in ADNI, individuals in the second Luminex t-tau subgroup had levels below the official cut-point defined by ADNI (i.e. 93 pg/ml [21]) and still showed higher HRs for progression to AD-type dementia compared to the first tau subgroup (HR (95%CI) = 2.1 (1.4, 3.0), p < .001).