A sensitivity analysis showed less mortality reduction with corticosteroids in women, patients < 60-year-old, with hypertension, cancer, or type 2 diabetes, CRP < 10 mg/dL, D-Dimer > 1500 ng/mL, ICU admission > 8 days after the onset of symptoms, corticosteroids within 7 days of symptom onset, Pa/FiO2 > 200, or APACHE score > 14 at ICU admission (Additional file 3: Table S2). This evidence concerns the gene CRP and Hypertension.