WFDC2 and neoplasm: Human epididymis protein 4 (HE4), has been proved to be a reliable biomarker for detecting ovarian cancer with a sensitivity of 76% (95%CI, 0.72–0.80) and a specificity of 94% (95%CI, 0.90–0.96) [29] and approved by the Food and Drug Administration in Unite State as a novel tumor biomarker for the diagnosis of ovarian cancer.