At signals S13 and 22, we also noted candidate genes with literature support: the nearest gene at signal S13 (notably supported by all three fracture look-ups) is SMC3, underlying Cornelia de Lange syndrome 3 (OMIM 610759) [65] and decreased BMC in mice, and the nearest gene to signal 22 is NRIP1, which is differentially expressed in patients with low vs. high BMD [52]. This evidence concerns the gene SMC3 and Cornelia de Lange syndrome.