This property was established with bivariable analyses and was illustrated with cross-classification analyses for both types of discordance: (1) high-adjusted MBDA score with low clinical disease activity, as was observed in 25% of patients with low DAS28-CRP and might occur in patients who have subclinical synovitis or are difficult to examine due to obesity or osteoarthritis and (2) low-adjusted MBDA score with high clinical disease activity, as was observed in 6% of patients with high DAS28-CRP and might occur in patients with fibromyalgia or other forms of non-inflammatory pain (Fig. 3a). The gene discussed is CRP; the disease is osteoarthritis.