AKT1 and cancer: In terms of downregulated DEGs, the pathway enrichment analysis results focused on focal adhesion, human papillomavirus infection, ECM-receptor interaction, protein digestion and absorption, vascular smooth muscle contraction, PI3K-Akt signaling pathway, PPAR signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway, and proteoglycans in cancer (Fig. 4b).