For example, a set of biomarkers composed of 6 miRNAs (miR-21, let-7 g, miR-31, miR-92a, miR-181b and miR-203) can be used to diagnose CRC, with higher sensitivity and specificity than carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) [16]. The gene discussed is CEACAM5; the disease is colorectal carcinoma.