Through a series of intracellular signaling pathways, highly malignant tumor cells express high levels of matrix metalloproteinase and other substances, degrading some substances such as laminin and remodeling the ECM, which promotes the migration of tumor cells and their transformation to a malignant phenotype, providing a stretching space and soil for the formation of a VM network [9, 28]. Here, LAMB2 is linked to neoplasm.