On one hand, FAK mediates the phosphorylation of Paxillin at local adhesion sites, thereby regulating focal adhesion, increasing tumor cell fluidity, and contributing to VM development [195]; on the other hand, FAK regulates MMP-2 and MT1-MMP activities through Erk1/2, thereby promoting ECM remodeling [196]. The gene discussed is MMP2; the disease is neoplasm.