The Hh pathway component Gli1 can be transported to the nucleus to induce the expression of its downstream stemness transcription factors, Nanog, Oct-4, and Sox-2; Gli1 can also bind to the Bmi1 promoter to increase Bmi1 transcription [82], thereby jointly enhancing the tumor stem phenotype in a hypoxic environment [83]. The gene discussed is GLI1; the disease is neoplasm.