The selectivity of transcriptional repression mediated by THZ1 is linked to CDK7-dependent enhancer remodeling, which is a possible explanation for the transcription addiction of identity genes and has been thoroughly identified in MYCN-amplified neuroblastoma [15], triple-negative breast cancer [16], T cell lymphoma [17] and small cell lung cancer [18]. The gene discussed is CDK7; the disease is triple-negative breast carcinoma.