Ninjurin2 (NINJ2) is a transmembrane protein that mediates cell-to-cell and cell-to-extracellular matrix interactions during development, differentiation, and regeneration of nervous system, the genetic polymorphisms of NINJ2 were associated with a decreased risk of Alzheimer’s disease [13], ischemic stroke [14] and large artery atherosclerotic stroke [15]. Here, NINJ2 is linked to early-onset autosomal dominant Alzheimer disease.