SIX1 and open-angle glaucoma: In that study, the researchers included two groups, African-Americans and Ghanaians and analyzed 57 SNPs in five loci including CDKN2B/CDKN2B-AS1, TMCO1, CAV1/CAV2, chromosome 8q22 intergenic region, and SIX1/SIX6. rs10120688 in CDKN2B-AS1 region was found to be associated with POAG in African Americans (p = 0.0020) [41].