The association of CDKN2B (rs3217992, rs1063192) and CDKN2B-AS1 (rs2157719, rs4977756) gene polymorphisms with primary glaucoma cases was investigated in a total of 910 samples: 449 controls having cataract, 313 POAG cases and 148 PACG cases. The gene discussed is CDKN2B; the disease is open-angle glaucoma.