In 2003, Rampoldi et al. [4] found that UMOD protein formed globular masses within the cytoplasm of ADTKD-UMOD kidneys in immunopathology using anti-UMOD antibodies and confirmed these intra-cytoplasmic heaps by electron microscopy to be fibrillary material. Here, UMOD is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.