APP and amyloidosis: These studies demonstrate that the GF diets, when started at the time or before amyloid deposition and continued for four months, in the transgenic mice expressing familial AD (FAD) mutant AβPP and presenilin 1 (PS1) cDNAs (AβPP-PS1), we were able to significantly attenuate amyloid plaque burden, levels of Aβ peptide, cathepsin B levels (inflammation) and increased brain NGF when compared to AβPP-PS1 control mice.