GJA1 and bipolar disorder: In order to clarify the more detailed pathomechanisms of bipolar disorder and pathophysiology of mood-stabilising actions, the effects of the mood-stabilising antipsychotics olanzapine, quetiapine, etc., and the mood-stabilising anticonvulsants valproate, carbamazepine, and lacosamide on astroglial Cx43 expression and the function of the Cx43 hemichannel and gap junction should be studied with both in vivo and in vitro preclinical studies.