Interestingly, the water-soluble partition of methanol or ethanol extracts successfully protected SK-N-SH neuroblastoma cells from cytotoxicity and inhibited the increases in ROS levels and caspase 3 activity induced by Aβ(1–42) or H2O2 and polychlorinated biphenyls treatments, respectively [52]. This evidence concerns the gene CASP3 and neuroblastoma.