Compared with the narrative or systematic review articles that have been recently published on this topic [6,7,17,18,33,34], to the best of our knowledge, this is the first comprehensive and updated meta-analysis of placebo-controlled or active-controlled RCTs that used various SGLT-2 inhibitors for treatment of NAFLD. This evidence concerns the gene SLC5A2 and metabolic dysfunction-associated steatotic liver disease.