Regarding the biological mechanism by which ACEs cause sleep problems, “altered corticotropin-releasing hormone (CRH) reactivity related to altered hypothalamic-pituitary-adrenal (HPA) axis functioning induced by ACEs may contribute to alterations in sleep regulation”, which is a well-recognized biological mechanism that is commonly observed in people with depression or anxiety [12]. The gene discussed is CRH; the disease is depressive symptom measurement.