In a mice model of genetic dyslipidemia and intestinal inflammation, supplementation with a mixture of probiotic strains, including Streptococcus thermophiles, Bifidobacterium breve, Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, and Lactobacillus helveticus modified the nuclear receptors’ expression including VDR, and caused their direct transactivation, leading to reversing insulin resistance in liver and fat tissues and protecting against steatohepatitis and atherosclerosis [40]. This evidence concerns the gene INS and metabolic syndrome.