EDNRB and Werner syndrome: As mentioned above, certain subtypes of WS type 2, TADS, and COMMAD syndrome can be attributed to pathogenic variants in MITF, while other types of WS are linked to pathogenic variants in PAX3, SNAI2, SOX10, EDNRB, EDN3, and KITLG. These genes are crucial for the differentiation and migration of melanocytes.