MITF and coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness: In contrast to WS type 2A and TADS, which are associated with autosomal-dominant MITF mutations, COMMAD syndrome seems to be associated with an autosomal recessive inheritance of MITF, suggesting a crucial role for MITF in ocular morphogenesis and bone homeostasis [11].