Adjuvant immunotherapies that have been used in melanoma clinical trials are: Interferon-α-2b (IFN-α-2b), Interleukin (IL)-2, melanoma cell vaccines, BCG (Bacillus Calmette-Guérin), and immune checkpoint inhibitors (ICI) immunotherapy in post-surgical, disease-free AJCC (American Joint Committee on Cancer) stage III and IV patients [1,2,3,4]. The gene discussed is IFNA2; the disease is melanoma.