Thus, for women with PCOS, a carefully prepared low-calorie diet to keep healthy weight or for weight loss for improvement of insulin resistance and metabolic- and reproductive functions, and restriction on the intake of simple sugar or refined carbohydrate, foods of low glycemic index, saturated trans-fatty acid, and taking care of deficiency in vitamin D, chromium, and Omega-3, were suggested [29]. Here, INS is linked to polycystic ovary syndrome.