Some of the metabolic and genetic changes that are reported in tumor cells are enhanced glycolysis, differential expression of lactate dehydrogenase A (LDH), which is linked with cancer growth and metastasis, mutations in metabolic enzymes such as isocitrate dehydrogenase 1 (IDH1), succinate dehydrogenase (SDH) and fumarate hydratase (FH) involved in initiating tumors [3]. The gene discussed is FH; the disease is neoplasm.