A significant association of low ADC values and hypoxia, as detected by FMISO-PET, was also reported for head and neck cancers in a recent study by Wiedenmann et al. [51] although a previous study described no significant correlation between the ADC and HIF-1α in oropharyngeal carcinoma [52]. The gene discussed is HIF1A; the disease is oropharyngeal carcinoma.