GLO1 and chronic myelogenous leukemia, BCR-ABL1 positive: Interestingly, during chronological aging, the expression of Glo1 was reversed in the basal layer of the epidermis, implying that overexpression of Glo1 may act as a protective mechanism where it protects the skin progenitor cells from the basal epidermal layer against aging-dependent protein modifications, which also explains the lesser accumulation of CML-modified AGE.