SOD2 and familial pancreatic carcinoma: In pancreatic cancer, overexpression of reactive oxygen species (ROS)-detoxifying genes superoxide dismutase 2 (SOD2) and catalase (CAT) and downregulation of gemcitabine-metabolizing enzyme deoxycytidine kinase (DCK) confers cellular chemoresistance through exosome-derived miRNA-155 [174].