Bhuvaneshwar et al. used the TARGET and Inova Pediatric Group Osteosarcoma Patients datasets and identified single nucleotide polymorphisms (SNPs) involved in tumor resistance and low rates of tumor necrosis, including variants of SLC22A1, SLC22A8, UGT2B15, and CHST12 [21]. This evidence concerns the gene SLC22A1 and neoplasm.