Bhuvaneshwar et al. used the TARGET and Inova Pediatric Group Osteosarcoma Patients datasets and identified single nucleotide polymorphisms (SNPs) involved in tumor resistance and low rates of tumor necrosis, including variants of SLC22A1, SLC22A8, UGT2B15, and CHST12 [21]. The gene discussed is SLC22A8; the disease is neoplasm.