More in detail, AAC1 is significantly (p < 0.001) downregulated in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), kidney renal or renal papillary cell carcinoma (KIRC, KIRP), cholangiocarcinoma (CHOL), esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), lung adenocarcinoma or squamous cell carcinoma (LUAD, LUSC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), and stomach adenocarcinoma (STAD) as observed in the available TCGA cancer tissues compared to the corresponding non-tumor counterpart (Figure 1). This evidence concerns the gene SLC25A4 and papillary renal cell carcinoma.