More in detail, AAC1 is significantly (p < 0.001) downregulated in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), kidney renal or renal papillary cell carcinoma (KIRC, KIRP), cholangiocarcinoma (CHOL), esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), lung adenocarcinoma or squamous cell carcinoma (LUAD, LUSC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), and stomach adenocarcinoma (STAD) as observed in the available TCGA cancer tissues compared to the corresponding non-tumor counterpart (Figure 1). The gene discussed is SLC25A4; the disease is squamous cell carcinoma.