Given its important role in cancer progression, anti-apoptotic members of the Bcl-2 family have been studied as therapeutic targets in cancer, first by using antisense oligonucleotides against BCL2 and Bcl-xL, and more recently by using the small molecule compounds called BH3-mimetics since they emulate the function of the BH3-only proteins. This evidence concerns the gene BCL2 and cancer.