NOTCH1 and laryngeal carcinoma: Very recently it has been demonstrated that up-regulation of miR-449a suppresses the proliferation as well as the migration and invasion of laryngeal carcinoma cells targeting Notch1 and Notch2 down-regulation and it has been suggested that miR-449a, alone or in combination therapy with Notch inhibitors, could be used as a potential tool to treat metastatic laryngeal carcinoma [51].