Finally, in HepG2 human hepatoma cell line, up-regulation of miR-21-3b by berberine an isoquinoline alkaloid extracted from many medicinal herbs, reduced the expression of MAT2A and MAT2B resulting in increased intracellular AdoMet levels which acted as a key regulator for hepatoma cell proliferation [60]. The gene discussed is MAT2A; the disease is hepatocellular carcinoma.