MAT1A and hepatocellular carcinoma: Recent studies reported that in human hepatocellular carcinoma (HCC) aberrant expression of miRNA induces dysregulation of methionine adenosyltransferase (MAT) isoforms responsible for maintaining adequate AdoMet cellular levels and that depletion of AdoMet results in increased HCC cell proliferation, a decrease in AdoMet is due to mutations in MAT1A gene.