In order to understand the degree to which our IFN-γ-treated HIO model recapitulates aspects of Crohn’s disease (CD) and ulcerative colitis (UC), the two main forms of IBD, we compared our gene expression data against publicly available datasets, contrasting gene expression of in vivo biopsy tissue from patients with IBD against healthy control [22]. Here, IFNG is linked to ulcerative colitis.