Furthermore, NK cell membrane proteins such as RAB-10, IRGM1, RANKL Galectin-12, and CB1, can interact with macrophage surface receptors such as tumor necrosis factor or receptor toll-like receptor 4, to prompt or increase pro-inflammatory M1 macrophage polarization, which would kill tumor cells directly by secreting reactive oxygen species (ROS) and nitrogen radicals [110,111,112]. This evidence concerns the gene TNF and neoplasm.