TLR4 and HIV infectious disease: In addition, we found that the G allele of the rs4986791 SNP in the TLR4 gene is strongly related to susceptibility to HIV infection in three Caucasian populations (odd ratio = 2.29, 95% confidence interval: 1.72–3.07, p = 1.438 × 10−7) and all four populations (odd ratio = 2.22, 95% confidence interval: 1.74–2.84, p = 2 × 10−10) in a meta-analysis.