In research on ALS, the most common neurodegenerative motor neuron disease occurring in adulthood, FGF-2 isoform-specific ko mice were used to further elucidate the neuroprotective effect of complete or hemizygous ko of FGF-2 seen in mutant SOD1G93A mice [104]. This evidence concerns the gene FGF2 and amyotrophic lateral sclerosis.