AHR and breast cancer: To illustrate this point here, we developed a biomarker set of genes regulated by the AHR in cancer by transcriptional profiling triple negative MDA-MB-231 breast cancer cells and triple negative SUM149 inflammatory breast cancer cells after CRISPR/Cas9-mediated AHR deletion (Figure 3a) and correlated the set of genes down-regulated in both knockouts with patient survival.