Further, AHR hyper-activation with the endogenous ligand FICZ [148,203,204] induced migration and invasion-associated (Snai1, Twist1, Twist2, Tgfb1, Vim) and stem cell-associated (Notch1, Notch2, Bmi1, Nanog, Sox2, Dppa3) genes in triple negative ALDHhigh breast cancer CSCs [162]. The gene discussed is AHR; the disease is breast carcinoma.