37% (n = 89) of OPSCC presented with high numbers of CD8+ TILs in their tumor microenvironment (TME) and this was significantly correlated with LAG-3, TIM-3 and VISTA expression in the whole cohort (p < 0.001, p < 0.001, p = 0.007). The gene discussed is CD8A; the disease is neoplasm.