LAG-3, TIM-3 and VISTA expression on immune cells was associated with an inflamed tumor microenvironment (CD8+ TILs) in the entire cohort (p < 0.001, p < 0.001, p = 0.007,) and in HPV-related OPSCC (p = 0.001, p < 0.001, p < 0.001). Here, LAG3 is linked to neoplasm.