HMGB1 and chronic cystitis: Many studies from different groups, including ours, have shown that HMGB1-nAb, developed by Nishibori et al. (Table 1) [21,22], strongly suppresses inflammatory pain [28], neuropathic pain by surgical injury of the sciatic nerve [31,91] or spinal nerve [76], and visceral pain following cystitis or pancreatitis [19,20,30,32].