MMP11 and breast cancer: Differently, co-culture of BC-PBMC with CAF showed significant increased expression of IL6 and IL10 in CAF, as observed in all PBMC-fibroblast co-cultures, however a specific increase of IL1A and NFĸB and a decrease of MMP11 gene expression were observed in CAF after co-culture with BC-PBMC (Figure 4E).