In addition to these, an association between circulating tumor cells with epithelial-mesenchymal transition (CTC-EMT) and MMP1 expression in primary tumor tissue has been reported, suggesting that therapeutic targeting of MMP1 could lead to a decrease in MMP1-induced EMT and, subsequently, decrease CTC-EMT and then cause a reduction in tumor dissemination or treatment resistance [32]. The gene discussed is MMP1; the disease is neoplasm.