NFKB1 and hepatocellular carcinoma: Taking into consideration the differences in the mechanism of COX inhibition by these two NSAIDs, the aim of this study was to appraise the effect of the new synthesized conjugates of previously investigated OAO derivatives with indomethacin on Nrf2 and NF-κB signaling in connection with cell cycle distribution, apoptosis, and proliferation in normal hepatocytes and HCC cell lines.