Although the analysis showed the 26 risk variants were not associated with an elevated risk for POAG, SNP analysis of the CG genotype of rs5335 in EDNRA showed a protective effect (OR 0.5, 95%CI: 0.3–0.9, p = 0.03), as did a haplotype analysis of CYP1B1 [119]. This evidence concerns the gene EDNRA and open-angle glaucoma.