They identified 11 POAG-associated loci: 4 known (ABCA1, AFAP1, CDKN2B-AS1, and SIX6) and 7 novel (ANKRD55-MAP3K1, FNDC3B, HMGA2, LHPP, LMX1B, LOXL1, and MEIS2) (p < 5.0 × 10−8) [47]. The gene discussed is SIX6; the disease is open-angle glaucoma.