They created a PRS that included risk variants from the 12 previously identified genes associated with POAG: ABCA1, AFAP1, ATXN2, CAV1, CDKN2B-AS1, FNDC3B, FOXC1, GAS7, GMDS, SIX1/SIX6, TMCO1, and TXNRD2. They discovered that the PRS was significantly associated with POAG (OR per 1-point increase in score = 1.24; 95% CI: 1.21–1.27; p = 3.4 × 10−66), as well as an earlier age at diagnosis (β = −0.36; 95% CI: −0.56 to −0.16; p = 4.0 × 10−4) [71]. The gene discussed is SIX6; the disease is open-angle glaucoma.