TTR and eye disorder: Additionally, seven genes known to be associated with other inherited eye diseases showed significantly enriched coding variants (ECVs): BEST1 (p = 0.04), FBN1 (p = 0.01), FOXC2 (p = 0.01), HK1 (p = 4.0 × 10−4), OPTN (p = 7.7 × 10−3), PIEZO2 (p = 7.3 × 10−4), and TTR (p = 6.7 × 10−3) (Table 2) [151].