In a study in mice, Silva et al. demonstrated that obesity aggravated the immune histopathological characteristics of the EoE experimental model, reducing the regulatory cytokines profile (low expression of forkhead box P3, FOXP3, and interleukin 10, IL-10), increasing the inflammatory mediators (IL-5 and thymic stromal lymphopoietin, TSLP), and promoting tissue remodeling [29]. Here, FOXP3 is linked to obesity due to melanocortin 4 receptor deficiency.