TSLP and obesity due to melanocortin 4 receptor deficiency: In a study in mice, Silva et al. demonstrated that obesity aggravated the immune histopathological characteristics of the EoE experimental model, reducing the regulatory cytokines profile (low expression of forkhead box P3, FOXP3, and interleukin 10, IL-10), increasing the inflammatory mediators (IL-5 and thymic stromal lymphopoietin, TSLP), and promoting tissue remodeling [29].