SHH and gastrointestinal disease: IPA showed significant changes in the expression levels of genes associated with gastrointestinal disease (Abcb1, Guca2a, Muc2, Rag2, Itga6, and Shh), inflammatory disease (Abcb1, Muc2, and Rag2), and cancer (Muc2, Guca2a, and Rag2) (Figure 4C).