WNT6 and basal cell carcinoma: CpG sites characterized by a switch from 5hmC to 5mC (n = 838, quadrangle VII in Figure 3B) and de novo gain of 5mC (n = 4730, quadrangle VIII in Figure 3B) were both found preferentially in genes involved in basal cell carcinoma signaling, e.g., Ctnnb1 and Wnt6 (Table 1).