DUOX2 and colorectal neoplasm: For instance, Duox2 is known to promote the progression of CRC [87], Tgm2 is overexpressed in human CRC tissue and is associated with increased cell proliferation [88], Cdhr5 is epigenetically downregulated in colorectal tumors [89], Hk2 is overexpressed in human CRC tissues and could potentially be a target for clinical treatment of CRC [90], and low expression of Gcnt3 is a high risk factor for relapse [91].