To verify this speculation, we sought to investigate the associations between AS severity and total serum IgE concentrations as well as the polymorphisms in the gene encoding the α-subunit of FcԑRI (FCER1A) representing the two tagging bins constituting the primary total serum IgE susceptibility loci [13,14,15,16]. The gene discussed is FCER1A; the disease is aortic stenosis.