In METABRIC cohort, patients in hot T-cell infiltrated were significantly associated with higher tumor grade (p < 0.0001), ER negative (p < 0.0001), PgR negative (p < 0.0001), TN (p < 0.0001), and claudin-low (p < 0.0001), compared with other groups. The gene discussed is ESR1; the disease is neoplasm.