That is, estrogen response gene sets were enriched in the TCGA BC cohort, while IFN-α response, IFN-γ response, TNF-α signaling via NFκB, IL6-JAK-STAT3 signaling, IL2-STAT5 signaling, and epithelial mesenchymal transition were enriched in METABRIC cohort. Here, STAT3 is linked to breast cancer.