CADM1 and neoplasm: Only 16 DMPs were not associated with platelets or coagulation factors which included hypermethylation of CADM1 and CADM2 and hypomethylation of LYST. CADM1 is known to be a tumor suppressor gene for solid tumors [55] including EOC [56] and is frequently inactivated by promoter hypermethylation [57].