Likewise, in agreement with the previous findings, in the current study, our results also indicated that V.A + LPS co-treatment significantly reversed LPS-induced increases in BACE-1 and Aβ levels in the indicated region (cortex and hippocampus) of mouse brain, indicating that anti-AD-like effects of V.A. Based on these findings, we suggest that the anti-amyloidogenic effect of V.A against LPS-induced amyloidogenesis might be possible via inhibition of the JNK-mediated amyloidogenic signaling pathway. This evidence concerns the gene MAPK8 and Alzheimer disease.