IFNG and myocarditis: Several experimental models of the T. cruzi infection suggest that CD4+ and CD8+ T cells-mediated Th-1 cytokine (IFN-γ, TNF-α, IL-12 and IL-18) response is important to control the parasites, while an uncontrolled production of these cytokines promotes myocarditis by inducing apoptosis of the cardiomyocytes and other immune cells [93,94,95].