In adriamycin-induced FSGS, 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (THSG) decreased albuminuria, lipid peroxidation, podocyte injury, renal fibrosis, and glomerulosclerosis, and induced Nrf2 nuclear translocation and HO-1 and NQO-1 gene expression [249]. Here, NFE2L2 is linked to focal segmental glomerulosclerosis.