In a model of LPS-induced AKI, treatment with dexmedetomidine, a selective α2 adrenal receptor (α2-AR) agonist, induced the expression of HO-1 and NQO-1 via the GSK-3β/Nrf2 signaling pathway, decreasing AKI pathological features [141,143]. This evidence concerns the gene NFE2L2 and acute kidney injury.