NFE2L2 and focal segmental glomerulosclerosis: In experimental FSGS, Keap1 knockdown mice displayed milder glomerulosclerosis (as reflected in decreased desmin-positive injured podocytes, and decreased gene expression of TGFβ1, fibronectin, Col4a4, and Col1a2), and preserved nephrin expression, indicating a beneficial impact of Nrf2 activation [248].