Studies in several experimental models of CKD, including subtotal nephrectomy, unilateral ureteral obstruction (UUO), or adenine-induced tubulointerstitial injury reported increased Keap1 expression and decreased Nrf2 nuclear translocation, leading to downregulation of antioxidant enzymes [180,181,182,183,188,189,190,191]. The gene discussed is KEAP1; the disease is chronic kidney disease.