Alpinetin, mangiferin, and pachymic acid activated Nrf2 and protected against LPS- or cecal-ligation and puncture-induced AKI, decreasing inflammatory cytokines such as TNF-α, IL-6, and IL-1β and/or suppressing the activation of the NRLP3 inflammasome [175,176,177]. The gene discussed is IL1B; the disease is acute kidney injury.