CGAS and cancer: Mir-93-5p was identified by studies examining EAC tissue miRNA; the combination of miR-25/miR-93 establishes an immunosuppressive microenvironment in breast cancer by inactivating the cGAS pathway [75], and it also reported to have the promotion function on cervical cancer by targeting THB2/Matrix metalloproteinases (MMPS) pathway [76] MiR-15a-5p is both up-regulated [37] and down-regulated [36,77] in cancer serum; some reports suggest that it acts as a tumor suppressor [47,78], whereas some suggest that it acts as a tumor promoter [48].