Since the tumor suppressor protein p53 upregulates sirtuin 6 via a deacetylation mechanism, histone H3 and p53 acetylation (via suppression of sirtuin 6) by TSA has a robust action on cancer cells as the posttranslational modification mediated by acetylation restores the regulation of p53 to normal physiological conditions [63]. This evidence concerns the gene SIRT6 and cancer.