ABCC6 and pseudoxanthoma elasticum (inherited or acquired): The diagnosis of PXE, which is based on cutaneous findings with characteristic histopathology, as well as ocular findings, combined with family history and/or demonstration of pathogenic sequence variants in the ABCC6 gene, implies that the patients are susceptible for development of serious ocular and cardiovascular manifestations with high degree of morbidity and occasional mortality [5,6].