For example, Wu et al. [197] found that targeting chemokine receptor CXCR4—which is overexpressed in glioblastoma and associated with a poor prognosis—in addition to PD-1 led to a significant decrease in MDSCs and increased circulating inflammatory anti-tumoral cytokines such as interferon-γ and TNF-α. The gene discussed is TNF; the disease is glioblastoma.